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Target Snapshot

CHEMBL2125 Target Snapshot

Vesicular acetylcholine transporter · SINGLE PROTEIN · Rattus norvegicus

90Compounds
18Assays
2Approved Drugs
97.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q62666. Use UniProt Q62666 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q62666 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Vesicular acetylcholine transporter as ChEMBL target CHEMBL2125, mapped to UniProt Q62666. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Vesicular acetylcholine transporter
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2125
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q62666
Vesicular acetylcholine transporter
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Vesicular acetylcholine transporter is the right protein anchor across sources, using UniProt Q62666 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVesicular acetylcholine transporter
UniProt AccessionQ62666
Component TypeProtein
Sequence Length530 aa

Vesicular acetylcholine transporter

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Vesicular acetylcholine transporter, mapped to UniProt Q62666. Sequence length is 530 aa.

Mapped IDQ62666
Review nameVesicular acetylcholine transporter
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC501.0
KI93.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL87379 8.88 Ki 1.32 Preclinical
CHEMBL2064618 8.76 Kd 1.73 Preclinical
CHEMBL1929421 8.59 Ki 2.58 Preclinical
CHEMBL1271961 8.43 Ki 3.68 Preclinical
CHEMBL1271907 8.16 Ki 6.95 Preclinical
CHEMBL3589727 8.14 Ki 7.3 Preclinical
CHEMBL2374420 8.13 Kd 7.4 Preclinical
CHEMBL2064616 8.03 Ki 9.3 Preclinical
CHEMBL1271906 7.96 Ki 10.9 Preclinical
CHEMBL3589728 7.94 Ki 11.5 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
11
5.5
14
6.0
11
6.5
14
7.0
17
7.5
5
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

HALOPERIDOL
CHEMBL54
Approved 1967
Assay Landscape

Assay Landscape

18
Total Assays
81
Tested Compounds
1
Assay Types
Binding — 18 assays, 81 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 8 10 7.2
cell-based format 7 67 6.7
cell membrane format 2 3 7.5
single protein format 1 1 7.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine