Hepatic triacylglycerol lipase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P11150. Use UniProt P11150 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11150 as the stable identity anchor, then attach disease evidence before program review.
Hepatic triacylglycerol lipase
Review this target as Hepatic triacylglycerol lipase, mapped to UniProt P11150. Sequence length is 499 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hepatic triacylglycerol lipase as ChEMBL target CHEMBL2127, mapped to UniProt P11150. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Hepatic triacylglycerol lipase is the right protein anchor across sources, using UniProt P11150 as the stable mapping.
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| Preferred Name | Hepatic triacylglycerol lipase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11150 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hepatic triacylglycerol lipase |
| UniProt Accession | P11150 |
| Component Type | Protein |
| Sequence Length | 499 aa |
Hepatic triacylglycerol lipase
Review this target as Hepatic triacylglycerol lipase, mapped to UniProt P11150. Sequence length is 499 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3677564 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL3677538 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL3677562 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL3677604 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL4460999 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL3672652 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3677630 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3677580 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL3677632 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL3672654 | 8.72 | IC50 | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 39 | 7.3 |
| single protein format | 5 | 327 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 14 | 6.8 |