Indolethylamine N-methyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O95050. Use UniProt O95050 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O95050 as the stable identity anchor, then attach disease evidence before program review.
Indolethylamine N-methyltransferase
Review this target as Indolethylamine N-methyltransferase, mapped to UniProt O95050. Sequence length is 263 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Indolethylamine N-methyltransferase as ChEMBL target CHEMBL2131, mapped to UniProt O95050. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Indolethylamine N-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O95050 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Indolethylamine N-methyltransferase |
| UniProt Accession | O95050 |
| Component Type | Protein |
| Sequence Length | 263 aa |
Indolethylamine N-methyltransferase
Review this target as Indolethylamine N-methyltransferase, mapped to UniProt O95050. Sequence length is 263 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3228343 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL3228332 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL418052 | 5.7 | Ki | 2000.0 | Preclinical |
| CHEMBL3228352 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL3228354 | 5.58 | IC50 | 2600.0 | Preclinical |
| CHEMBL3228372 | 5.55 | IC50 | 2800.0 | Preclinical |
| CHEMBL3228261 | 5.48 | IC50 | 3300.0 | Preclinical |
| CHEMBL4591248 | 5.47 | IC50 | 3400.0 | Preclinical |
| CHEMBL3228381 | 5.43 | IC50 | 3700.0 | Preclinical |
| CHEMBL1214186 | 5.4 | IC50 | 4000.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 16 | 0 | — |
| single protein format | 9 | 37 | 5.0 |
| tissue-based format | 7 | 0 | — |
| assay format | 5 | 0 | — |
| cell-based format | 1 | 1 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 1 | 5.5 |