Tryptophan 2,3-dioxygenase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P48775. Use UniProt P48775 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48775 as the stable identity anchor, then attach disease evidence before program review.
Tryptophan 2,3-dioxygenase
Review this target as Tryptophan 2,3-dioxygenase, mapped to UniProt P48775. Sequence length is 406 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tryptophan 2,3-dioxygenase as ChEMBL target CHEMBL2140, mapped to UniProt P48775. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Tryptophan 2,3-dioxygenase is the right protein anchor across sources, using UniProt P48775 as the stable mapping.
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| Preferred Name | Tryptophan 2,3-dioxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P48775 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tryptophan 2,3-dioxygenase |
| UniProt Accession | P48775 |
| Component Type | Protein |
| Sequence Length | 406 aa |
Tryptophan 2,3-dioxygenase
Review this target as Tryptophan 2,3-dioxygenase, mapped to UniProt P48775. Sequence length is 406 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5220107 | 8.47 | IC50 | 3.42 | Preclinical |
| CHEMBL4787695 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5203175 | 8.02 | IC50 | 9.6 | Preclinical |
| CHEMBL4765090 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5991135 | 7.94 | IC50 | 11.6 | Preclinical |
| CHEMBL4756155 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL4780314 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4747779 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL5767906 | 7.8 | IC50 | 15.8 | Preclinical |
| CHEMBL4753714 | 7.75 | IC50 | 18.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 72 | 303 | 5.8 |
| cell-based format | 40 | 321 | 6.1 |
| assay format | 36 | 507 | 5.9 |