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Target Snapshot

CHEMBL2146298 Target Snapshot

Protein skinhead-1 · SINGLE PROTEIN · Caenorhabditis elegans

1,404Compounds
4Assays
0Approved Drugs
1,832.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P34707. Use UniProt P34707 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P34707 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein skinhead-1 as ChEMBL target CHEMBL2146298, mapped to UniProt P34707. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein skinhead-1
SINGLE PROTEIN · Caenorhabditis elegans
As of 2026-09-14
ChEMBL target ID
CHEMBL2146298
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P34707
Protein skinhead-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein skinhead-1 is the right protein anchor across sources, using UniProt P34707 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein skinhead-1
UniProt AccessionP34707
Component TypeProtein
Sequence Length623 aa

Protein skinhead-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein skinhead-1, mapped to UniProt P34707. Sequence length is 623 aa.

Mapped IDP34707
Review nameProtein skinhead-1
OrganismCaenorhabditis elegans
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC501,832.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3182429 6.61 IC50 244.0 Preclinical
CHEMBL1428659 6.19 IC50 640.0 Preclinical
CHEMBL3187737 6.12 IC50 767.0 Preclinical
CHEMBL1575487 6.08 IC50 826.0 Preclinical
CHEMBL1311572 5.98 IC50 1040.0 Preclinical
CHEMBL1462983 5.96 IC50 1100.0 Preclinical
CHEMBL3182577 5.82 IC50 1510.0 Preclinical
CHEMBL1403349 5.8 IC50 1580.0 Preclinical
CHEMBL1408099 5.75 IC50 1790.0 Preclinical
CHEMBL3182531 5.71 IC50 1960.0 Preclinical
Distribution

pChEMBL Value Distribution

78
5.0
17
5.5
3
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
401
Tested Compounds
1
Assay Types
Functional — 4 assays, 401 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 401 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine