Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q14191. Use UniProt Q14191 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14191 as the stable identity anchor, then attach disease evidence before program review.
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Review this target as Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, mapped to UniProt Q14191. Sequence length is 1432 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN as ChEMBL target CHEMBL2146312, mapped to UniProt Q14191. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14191 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
| UniProt Accession | Q14191 |
| Component Type | Protein |
| Sequence Length | 1432 aa |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Review this target as Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, mapped to UniProt Q14191. Sequence length is 1432 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1091250 | 6.7 | IC50 | 200.0 | Approved |
| CHEMBL1968672 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL2426164 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL2426190 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL2426169 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL1353989 | 5.64 | IC50 | 2300.0 | Preclinical |
| CHEMBL5564300 | 5.64 | IC50 | 2305.0 | Preclinical |
| CHEMBL2426168 | 5.57 | IC50 | 2700.0 | Preclinical |
| CHEMBL2426161 | 5.54 | IC50 | 2900.0 | Preclinical |
| CHEMBL1374426 | 5.52 | IC50 | 3000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 28 | 4.6 |
| single protein format | 5 | 13 | 5.4 |
| assay format | 1 | 1 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |