PTPsigma-(Brain) · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UM81. Use UniProt Q9UM81 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UM81 as the stable identity anchor, then attach disease evidence before program review.
Receptor-type tyrosine-protein phosphatase S
Review this target as PTPsigma-(Brain), mapped to UniProt Q9UM81. ChEMBL maps the protein component as Receptor-type tyrosine-protein phosphatase S. Sequence length is 1502 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats PTPsigma-(Brain) as ChEMBL target CHEMBL2146342, mapped to UniProt Q9UM81. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | PTPsigma-(Brain) |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UM81 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Receptor-type tyrosine-protein phosphatase S |
| UniProt Accession | Q9UM81 |
| Component Type | Protein |
| Sequence Length | 1502 aa |
Receptor-type tyrosine-protein phosphatase S
Review this target as PTPsigma-(Brain), mapped to UniProt Q9UM81. ChEMBL maps the protein component as Receptor-type tyrosine-protein phosphatase S. Sequence length is 1502 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2146956 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL399586 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL2146957 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL2146960 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL2146958 | 6.05 | IC50 | 900.0 | Preclinical |
| CHEMBL2057830 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL2146959 | 5.89 | IC50 | 1300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 7 | 6.3 |