Tyrosine-protein kinase JAK3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tyrosine-protein kinase JAK3 shows approved-linked disease relevance led by rheumatoid arthritis. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P52333. Start with rheumatoid arthritis, then reuse UniProt P52333 as the stable protein anchor across project notes and exports.
Start with rheumatoid arthritis, then reuse UniProt P52333 as the stable protein anchor across project notes and exports.
Tyrosine-protein kinase JAK3 shows approved-linked disease relevance led by rheumatoid arthritis. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.
Start review with rheumatoid arthritis because it currently carries approved-linked support. Linked drugs include DECERNOTINIB, FILGOTINIB, FILGOTINIB MALEATE, RITLECITINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosine-protein kinase JAK3
Review this target as Tyrosine-protein kinase JAK3, mapped to UniProt P52333. Sequence length is 1124 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase JAK3 as ChEMBL target CHEMBL2148, mapped to UniProt P52333. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tyrosine-protein kinase JAK3 is the right protein anchor across sources, using UniProt P52333 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why rheumatoid arthritis is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tyrosine-protein kinase JAK3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P52333 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase JAK3 |
| UniProt Accession | P52333 |
| Component Type | Protein |
| Sequence Length | 1124 aa |
Tyrosine-protein kinase JAK3
Review this target as Tyrosine-protein kinase JAK3, mapped to UniProt P52333. Sequence length is 1124 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosine-protein kinase JAK3 shows approved-linked disease relevance led by rheumatoid arthritis. 5 more disease programs remain visible in the same review block.
Start review with rheumatoid arthritis because it currently carries approved-linked support. Linked drugs include DECERNOTINIB, FILGOTINIB, FILGOTINIB MALEATE, RITLECITINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3335689 | 10.98 | Ki | 0.01046 | Preclinical |
| CHEMBL3335699 | 10.98 | Ki | 0.01055 | Preclinical |
| CHEMBL3665184 | 10.98 | IC50 | 0.01051 | Preclinical |
| CHEMBL3665122 | 10.98 | IC50 | 0.01047 | Preclinical |
| CHEMBL3665173 | 10.97 | Ki | 0.01074 | Preclinical |
| CHEMBL3665213 | 10.97 | Ki | 0.01081 | Preclinical |
| CHEMBL3665193 | 10.97 | IC50 | 0.01071 | Preclinical |
| CHEMBL3665200 | 10.96 | IC50 | 0.01096 | Preclinical |
| CHEMBL3665167 | 10.93 | Ki | 0.01179 | Preclinical |
| CHEMBL3665172 | 10.93 | IC50 | 0.01175 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 941 | 6,385 | 7.3 |
| cell-based format | 151 | 474 | 7.0 |
| assay format | 120 | 460 | 7.5 |
| organism-based format | 7 | 8 | 6.7 |
| subcellular format | 5 | 0 | — |
| tissue-based format | 1 | 1 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 35 | 2 | 7.1 |
| assay format | 2 | 236 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 7 | 7.6 |
| assay format | 2 | 29 | 6.7 |
| cell-based format | 2 | 1 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |