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Target Snapshot

CHEMBL2150835 Target Snapshot

Enoyl-[acyl-carrier-protein] reductase [NADH] · SINGLE PROTEIN · Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)

12Compounds
10Assays
5Approved Drugs
31.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q5NGQ3. Use UniProt Q5NGQ3 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5NGQ3 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Enoyl-[acyl-carrier-protein] reductase [NADH] as ChEMBL target CHEMBL2150835, mapped to UniProt Q5NGQ3. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Enoyl-[acyl-carrier-protein] reductase [NADH]
SINGLE PROTEIN · Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
As of 2026-09-13
ChEMBL target ID
CHEMBL2150835
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q5NGQ3
Enoyl-[acyl-carrier-protein] reductase [NADH]
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Enoyl-[acyl-carrier-protein] reductase [NADH] is the right protein anchor across sources, using UniProt Q5NGQ3 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEnoyl-[acyl-carrier-protein] reductase [NADH]
UniProt AccessionQ5NGQ3
Component TypeProtein
Sequence Length260 aa

Enoyl-[acyl-carrier-protein] reductase [NADH]

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Enoyl-[acyl-carrier-protein] reductase [NADH], mapped to UniProt Q5NGQ3. Sequence length is 260 aa.

Mapped IDQ5NGQ3
Review nameEnoyl-[acyl-carrier-protein] reductase [NADH]
OrganismFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Clinical Profile

Clinical Phase Distribution

5
Approved
Assay Mix

Activity Type Distribution

IC5028.0
KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL849 7.3 IC50 50.0 Approved
CHEMBL1341978 6.77 IC50 170.0 Preclinical
CHEMBL1390649 6.52 IC50 300.0 Preclinical
CHEMBL1945507 6.44 Ki 360.0 Preclinical
CHEMBL2398661 5.52 IC50 3000.0 Preclinical
CHEMBL2398661 5.47 Ki 3400.0 Preclinical
CHEMBL2398664 5.22 IC50 6000.0 Preclinical
CHEMBL1341978 5.16 Ki 7000.0 Preclinical
CHEMBL2398663 4.96 IC50 11000.0 Preclinical
CHEMBL2398662 4.35 IC50 45000.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
3
5.5
3
6.0
3
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TRICLOSAN
CHEMBL849
Approved 1997
Assay Landscape

Assay Landscape

10
Total Assays
12
Tested Compounds
1
Assay Types
Binding — 10 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 10 12 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine