ATPase family AAA domain-containing protein 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q6PL18. Use UniProt Q6PL18 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6PL18 as the stable identity anchor, then attach disease evidence before program review.
ATPase family AAA domain-containing protein 2
Review this target as ATPase family AAA domain-containing protein 2, mapped to UniProt Q6PL18. Sequence length is 1390 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ATPase family AAA domain-containing protein 2 as ChEMBL target CHEMBL2150837, mapped to UniProt Q6PL18. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | ATPase family AAA domain-containing protein 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6PL18 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ATPase family AAA domain-containing protein 2 |
| UniProt Accession | Q6PL18 |
| Component Type | Protein |
| Sequence Length | 1390 aa |
ATPase family AAA domain-containing protein 2
Review this target as ATPase family AAA domain-containing protein 2, mapped to UniProt Q6PL18. Sequence length is 1390 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5079885 | 8.9 | Kd | 1.259 | Preclinical |
| CHEMBL4206758 | 8.89 | Kd | 1.3 | Preclinical |
| CHEMBL5079885 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL3590405 | 8.1 | Kd | 7.943 | Preclinical |
| CHEMBL4449894 | 8.0 | Kd | 10.0 | Preclinical |
| CHEMBL5087319 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL3590408 | 7.7 | Ki | 19.95 | Preclinical |
| CHEMBL5090369 | 7.7 | IC50 | 19.95 | Preclinical |
| CHEMBL5093862 | 7.7 | IC50 | 19.95 | Preclinical |
| CHEMBL4536031 | 7.66 | IC50 | 22.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 47 | 131 | 5.7 |
| single protein format | 42 | 96 | 5.5 |
| cell-based format | 20 | 38 | 5.6 |