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Target Snapshot

CHEMBL2157851 Target Snapshot

Ubiquitin carboxyl-terminal hydrolase 47 · SINGLE PROTEIN · Homo sapiens

79Compounds
10Assays
0Approved Drugs
89.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q96K76. Use UniProt Q96K76 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96K76 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ubiquitin carboxyl-terminal hydrolase 47 as ChEMBL target CHEMBL2157851, mapped to UniProt Q96K76. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ubiquitin carboxyl-terminal hydrolase 47
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2157851
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q96K76
Ubiquitin carboxyl-terminal hydrolase 47
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ubiquitin carboxyl-terminal hydrolase 47 is the right protein anchor across sources, using UniProt Q96K76 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUbiquitin carboxyl-terminal hydrolase 47
UniProt AccessionQ96K76
Component TypeProtein
Sequence Length1375 aa

Ubiquitin carboxyl-terminal hydrolase 47

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ubiquitin carboxyl-terminal hydrolase 47, mapped to UniProt Q96K76. Sequence length is 1375 aa.

Mapped IDQ96K76
Review nameUbiquitin carboxyl-terminal hydrolase 47
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5066.0
EC5023.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5290347 6.7 EC50 200.0 Preclinical
CHEMBL2159507 6.46 IC50 350.0 Preclinical
CHEMBL4125810 6.44 EC50 360.0 Preclinical
CHEMBL4127188 6.44 EC50 360.0 Preclinical
CHEMBL2398212 6.4 IC50 400.0 Preclinical
CHEMBL5275791 6.35 EC50 450.0 Preclinical
CHEMBL2159505 6.3 IC50 500.0 Preclinical
CHEMBL2159503 6.28 IC50 530.0 Preclinical
CHEMBL2159504 6.06 EC50 870.0 Preclinical
CHEMBL2159504 6.06 IC50 870.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
17
5.5
16
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

10
Total Assays
41
Tested Compounds
1
Assay Types
Binding — 10 assays, 41 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 8 38 5.7
cell-based format 2 3 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine