Review anchor
NAD-dependent protein deacylase sirtuin-5, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
NAD-dependent protein deacylase sirtuin-5, mitochondrial
CHEMBL2163183
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD-dependent protein deacylase sirtuin-5, mitochondrial as ChEMBL target CHEMBL2163183, mapped to UniProt Q9NXA8. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2163183
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9NXA8
NAD-dependent protein deacylase sirtuin-5, mitochondrial
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why NAD-dependent protein deacylase sirtuin-5, mitochondrial matters
NAD-dependent protein deacylase sirtuin-5, mitochondrial is reviewed as NAD-dependent protein deacylase sirtuin-5, mitochondrial (UniProt Q9NXA8); the current evidence base includes 6 approved drugs, 832 compounds, and 225 assays, with lead potency reaching pChEMBL 11.0.
Protein context
NAD-dependent protein deacylase sirtuin-5, mitochondrial
NAD-dependent protein deacylase sirtuin-5, mitochondrial Sequence length is 310 aa.
Review this target as NAD-dependent protein deacylase sirtuin-5, mitochondrial, mapped to UniProt Q9NXA8. Sequence length is 310 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9NXA8
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 6 approved drugs, 832 compounds, and 225 assays for this target. The dominant activity type is IC50. CHEMBL4091790 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL4091790 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
6 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why NAD-dependent protein deacylase sirtuin-5, mitochondrial matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9NXA8, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
832
Total Compounds
225
Total Assays
6
Approved Drugs
IC50: 687.0, KI: 25.0, EC50: 4.0, KD: 10.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL4091790
|
11.0 | Kd | — |
|
|
No preferred name
CHEMBL4064460
|
9.9 | Kd | — |
|
|
No preferred name
CHEMBL5199270
|
9.3 | Ki | — |
|
|
No preferred name
CHEMBL4065067
|
8.5 | Ki | — |
|
|
No preferred name
CHEMBL4092751
|
8.5 | Ki | — |
Source Header