NAD-dependent protein lipoamidase sirtuin-4, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y6E7. Use UniProt Q9Y6E7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y6E7 as the stable identity anchor, then attach disease evidence before program review.
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Review this target as NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, mapped to UniProt Q9Y6E7. Sequence length is 314 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD-dependent protein lipoamidase sirtuin-4, mitochondrial as ChEMBL target CHEMBL2163185, mapped to UniProt Q9Y6E7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y6E7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
| UniProt Accession | Q9Y6E7 |
| Component Type | Protein |
| Sequence Length | 314 aa |
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Review this target as NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, mapped to UniProt Q9Y6E7. Sequence length is 314 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5574837 | 6.05 | IC50 | 900.0 | Preclinical |
| CHEMBL265502 | 5.7 | IC50 | 2000.0 | Clinical |
| CHEMBL5573193 | 5.0 | IC50 | 10000.0 | Preclinical |
| CHEMBL1140 | 4.89 | IC50 | 13000.0 | Approved |
| CHEMBL5579775 | 4.85 | IC50 | 14000.0 | Preclinical |
| CHEMBL5591891 | 4.8 | IC50 | 16000.0 | Preclinical |
| CHEMBL5574249 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL5573728 | 4.62 | IC50 | 24000.0 | Preclinical |
| CHEMBL5564142 | 4.48 | IC50 | 33000.0 | Preclinical |
| CHEMBL5594752 | 4.48 | IC50 | 33000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 18 | 4.7 |
| single protein format | 5 | 0 | — |
| assay format | 2 | 0 | — |