GTPase HRas · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P01112. Use UniProt P01112 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P01112 as the stable identity anchor, then attach disease evidence before program review.
GTPase HRas
Review this target as GTPase HRas, mapped to UniProt P01112. Sequence length is 189 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats GTPase HRas as ChEMBL target CHEMBL2167, mapped to UniProt P01112. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GTPase HRas is the right protein anchor across sources, using UniProt P01112 as the stable mapping.
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| Preferred Name | GTPase HRas |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P01112 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | GTPase HRas |
| UniProt Accession | P01112 |
| Component Type | Protein |
| Sequence Length | 189 aa |
GTPase HRas
Review this target as GTPase HRas, mapped to UniProt P01112. Sequence length is 189 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL351706 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL279433 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL66699 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL554189 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL554247 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL552690 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL554353 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL540313 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL552863 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL536328 | 7.7 | IC50 | 20.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 15 | 40 | 5.8 |
| assay format | 12 | 7 | 5.2 |
| cell-based format | 6 | 2 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 15 | 6.2 |