N-lysine methyltransferase SMYD2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9NRG4. Use UniProt Q9NRG4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NRG4 as the stable identity anchor, then attach disease evidence before program review.
N-lysine methyltransferase SMYD2
Review this target as N-lysine methyltransferase SMYD2, mapped to UniProt Q9NRG4. Sequence length is 433 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats N-lysine methyltransferase SMYD2 as ChEMBL target CHEMBL2169716, mapped to UniProt Q9NRG4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | N-lysine methyltransferase SMYD2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NRG4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | N-lysine methyltransferase SMYD2 |
| UniProt Accession | Q9NRG4 |
| Component Type | Protein |
| Sequence Length | 433 aa |
N-lysine methyltransferase SMYD2
Review this target as N-lysine methyltransferase SMYD2, mapped to UniProt Q9NRG4. Sequence length is 433 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5746366 | 8.58 | IC50 | 2.64 | Preclinical |
| CHEMBL3590526 | 8.55 | IC50 | 2.8 | Preclinical |
| CHEMBL5187983 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL3819011 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3590527 | 8.25 | IC50 | 5.6 | Preclinical |
| CHEMBL4536230 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3818617 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL4520134 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL4756148 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL5789916 | 7.88 | IC50 | 13.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 78 | 75 | 6.2 |
| cell-based format | 51 | 68 | 6.5 |
| assay format | 11 | 26 | 6.4 |
| tissue-based format | 7 | 0 | — |