Use UniProt Q8IBS5 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2169725 Target Snapshot
Calcium-dependent protein kinase 4 · SINGLE PROTEIN · Plasmodium falciparum (isolate 3D7)
Research home keeps recent targets
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Switch target
Move to another high-traffic target or paste a specific ChEMBL target ID.
Frame the target before identity details
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q8IBS5. Use UniProt Q8IBS5 as the stable identity anchor, then attach disease evidence before program review.
Calcium-dependent protein kinase 4
Review this target as Calcium-dependent protein kinase 4, mapped to UniProt Q8IBS5. Sequence length is 528 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Calcium-dependent protein kinase 4 as ChEMBL target CHEMBL2169725, mapped to UniProt Q8IBS5. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Start with the right source
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Calcium-dependent protein kinase 4 is the right protein anchor across sources, using UniProt Q8IBS5 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardBasic Information
Verify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Calcium-dependent protein kinase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
| UniProt | Q8IBS5 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Calcium-dependent protein kinase 4 |
| UniProt Accession | Q8IBS5 |
| Component Type | Protein |
| Sequence Length | 528 aa |
Calcium-dependent protein kinase 4
How to read this target
Review this target as Calcium-dependent protein kinase 4, mapped to UniProt Q8IBS5. Sequence length is 528 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2030554 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL2078876 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4591417 | 7.3 | Kd | 50.0 | Preclinical |
| CHEMBL4461850 | 7.22 | Kd | 60.0 | Preclinical |
| CHEMBL1231371 | 6.75 | IC50 | 177.0 | Preclinical |
| CHEMBL530978 | 6.16 | IC50 | 700.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 5 assays, 6 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 5 | 7.6 |
| assay format | 1 | 1 | — |
Functional — 2 assays, 1 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 6.2 |