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Target Snapshot

CHEMBL2176844 Target Snapshot

STE20-like serine/threonine-protein kinase · SINGLE PROTEIN · Mus musculus

1Compounds
1Assays
0Approved Drugs
1.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O54988. Use UniProt O54988 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O54988 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats STE20-like serine/threonine-protein kinase as ChEMBL target CHEMBL2176844, mapped to UniProt O54988. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
STE20-like serine/threonine-protein kinase
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL2176844
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O54988
STE20-like serine/threonine-protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether STE20-like serine/threonine-protein kinase is the right protein anchor across sources, using UniProt O54988 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSTE20-like serine/threonine-protein kinase
UniProt AccessionO54988
Component TypeProtein
Sequence Length1233 aa

STE20-like serine/threonine-protein kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as STE20-like serine/threonine-protein kinase, mapped to UniProt O54988. Sequence length is 1233 aa.

Mapped IDO54988
Review nameSTE20-like serine/threonine-protein kinase
OrganismMus musculus
Assay Mix

Activity Type Distribution

KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1802358 7.68 Kd 21.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 1 1 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine