Aurora kinase B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Aurora kinase B shows late clinical disease relevance led by small cell lung carcinoma. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q96GD4. Start with small cell lung carcinoma, then reuse UniProt Q96GD4 as the stable protein anchor across project notes and exports.
Start with small cell lung carcinoma, then reuse UniProt Q96GD4 as the stable protein anchor across project notes and exports.
Aurora kinase B shows late clinical disease relevance led by small cell lung carcinoma. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with small cell lung carcinoma because it currently carries late clinical support. Linked drugs include IBCASERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAurora kinase B
Review this target as Aurora kinase B, mapped to UniProt Q96GD4. Sequence length is 344 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Aurora kinase B as ChEMBL target CHEMBL2185, mapped to UniProt Q96GD4. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Aurora kinase B is the right protein anchor across sources, using UniProt Q96GD4 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why small cell lung carcinoma is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Aurora kinase B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q96GD4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aurora kinase B |
| UniProt Accession | Q96GD4 |
| Component Type | Protein |
| Sequence Length | 344 aa |
Aurora kinase B
Review this target as Aurora kinase B, mapped to UniProt Q96GD4. Sequence length is 344 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Aurora kinase B shows late clinical disease relevance led by small cell lung carcinoma. 5 more disease programs remain visible in the same review block.
Start review with small cell lung carcinoma because it currently carries late clinical support. Linked drugs include IBCASERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4225923 | 11.0 | Kd | 0.01 | Preclinical |
| CHEMBL3680444 | 10.38 | IC50 | 0.042 | Preclinical |
| CHEMBL3680508 | 10.35 | IC50 | 0.045 | Preclinical |
| CHEMBL3680447 | 10.34 | IC50 | 0.046 | Preclinical |
| CHEMBL3680552 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL3685243 | 10.21 | IC50 | 0.061 | Preclinical |
| CHEMBL3685277 | 10.05 | IC50 | 0.089 | Preclinical |
| CHEMBL4227082 | 10.0 | Kd | 0.1 | Preclinical |
| CHEMBL3675525 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL3680596 | 9.74 | IC50 | 0.18 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 728 | 1,775 | 7.0 |
| cell-based format | 265 | 264 | 6.7 |
| assay format | 108 | 127 | 6.9 |
| subcellular format | 23 | 53 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 16 | 0 | — |
| single protein format | 4 | 20 | 6.1 |
| assay format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 1 | 8.1 |
| assay format | 2 | 622 | 6.4 |