Histone-lysine N-methyltransferase EZH1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q92800. Use UniProt Q92800 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q92800 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase EZH1
Review this target as Histone-lysine N-methyltransferase EZH1, mapped to UniProt Q92800. Sequence length is 747 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone-lysine N-methyltransferase EZH1 as ChEMBL target CHEMBL2189116, mapped to UniProt Q92800. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone-lysine N-methyltransferase EZH1 is the right protein anchor across sources, using UniProt Q92800 as the stable mapping.
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| Preferred Name | Histone-lysine N-methyltransferase EZH1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q92800 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase EZH1 |
| UniProt Accession | Q92800 |
| Component Type | Protein |
| Sequence Length | 747 aa |
Histone-lysine N-methyltransferase EZH1
Review this target as Histone-lysine N-methyltransferase EZH1, mapped to UniProt Q92800. Sequence length is 747 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4597193 | 9.36 | IC50 | 0.44 | Clinical |
| CHEMBL5197386 | 9.33 | IC50 | 0.47 | Preclinical |
| CHEMBL5185991 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL6032817 | 8.08 | IC50 | 8.31 | Preclinical |
| CHEMBL5289464 | 8.07 | IC50 | 8.6 | Preclinical |
| CHEMBL5840996 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL5922751 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL3414574 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5791232 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL5956024 | 7.82 | IC50 | 15.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 51 | 67 | 6.9 |
| assay format | 4 | 1 | 6.8 |
| cell-based format | 4 | 1 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 7.2 |
| cell-based format | 1 | 0 | — |