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Target Snapshot

CHEMBL2210 Target Snapshot

Beta-casein · SINGLE PROTEIN · Rattus norvegicus

6Compounds
2Assays
1Approved Drugs
6.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P02665. Use UniProt P02665 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02665 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-casein as ChEMBL target CHEMBL2210, mapped to UniProt P02665. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-casein
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2210
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P02665
Beta-casein
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-casein is the right protein anchor across sources, using UniProt P02665 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-casein
UniProt AccessionP02665
Component TypeProtein
Sequence Length231 aa

Beta-casein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Beta-casein, mapped to UniProt P02665. Sequence length is 231 aa.

Mapped IDP02665
Review nameBeta-casein
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

KI6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL423294 9.85 Ki 0.1413 Preclinical
CHEMBL342062 9.68 Ki 0.2089 Preclinical
CHEMBL97698 9.57 Ki 0.2692 Preclinical
CHEMBL2 9.44 Ki 0.3631 Approved
CHEMBL267930 8.81 Ki 1.549 Clinical
CHEMBL140450 7.38 Ki 41.69 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
1
7.0
0
7.5
0
8.0
1
8.5
1
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

PRAZOSIN
CHEMBL2
Approved 1976
Assay Landscape

Assay Landscape

2
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 2 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 6 9.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine