Tumour suppressor protein p53/Mdm4 · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P04637. Use UniProt P04637 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04637 as the stable identity anchor, then attach disease evidence before program review.
Cellular tumor antigen p53
Review this target as Tumour suppressor protein p53/Mdm4, mapped to UniProt P04637. ChEMBL maps the protein component as Cellular tumor antigen p53. Sequence length is 393 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tumour suppressor protein p53/Mdm4 as ChEMBL target CHEMBL2221344, mapped to UniProt P04637. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Tumour suppressor protein p53/Mdm4 is the right protein anchor across sources, using UniProt P04637 as the stable mapping.
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| Preferred Name | Tumour suppressor protein p53/Mdm4 |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P04637 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cellular tumor antigen p53 |
| UniProt Accession | P04637 |
| Component Type | Protein |
| Sequence Length | 393 aa |
Cellular tumor antigen p53
Review this target as Tumour suppressor protein p53/Mdm4, mapped to UniProt P04637. ChEMBL maps the protein component as Cellular tumor antigen p53. Sequence length is 393 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5272028 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5283210 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL376408 | 9.1 | Ki | 0.8 | Preclinical |
| CHEMBL5268205 | 8.76 | IC50 | 1.74 | Preclinical |
| CHEMBL5276426 | 8.61 | IC50 | 2.46 | Preclinical |
| CHEMBL5282600 | 8.24 | IC50 | 5.77 | Preclinical |
| CHEMBL4095983 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL3621947 | 8.17 | Ki | 6.8 | Preclinical |
| CHEMBL5287696 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL191334 | 8.03 | IC50 | 9.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 18 | 72 | 6.1 |
| cell-based format | 8 | 8 | 7.3 |
| assay format | 1 | 7 | 5.3 |