Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q16665. Use UniProt Q16665 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16665 as the stable identity anchor, then attach disease evidence before program review.
Hypoxia-inducible factor 1-alpha
Review this target as Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha, mapped to UniProt Q16665. ChEMBL maps the protein component as Hypoxia-inducible factor 1-alpha. Sequence length is 826 aa.
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This review treats Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha as ChEMBL target CHEMBL2221345, mapped to UniProt Q16665. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | Q16665 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hypoxia-inducible factor 1-alpha |
| UniProt Accession | Q16665 |
| Component Type | Protein |
| Sequence Length | 826 aa |
Hypoxia-inducible factor 1-alpha
Review this target as Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha, mapped to UniProt Q16665. ChEMBL maps the protein component as Hypoxia-inducible factor 1-alpha. Sequence length is 826 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3335630 | 9.33 | IC50 | 0.47 | Preclinical |
| CHEMBL3335423 | 9.01 | IC50 | 0.97 | Preclinical |
| CHEMBL3335427 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL3335426 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL2021442 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL461308 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3335421 | 8.51 | IC50 | 3.1 | Preclinical |
| CHEMBL3335415 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL383824 | 8.44 | IC50 | 3.6 | Clinical |
| CHEMBL3335425 | 8.24 | IC50 | 5.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 136 | 243 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 13 | 5.1 |