Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) · PROTEIN COMPLEX · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P51787. Use UniProt P51787 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51787 as the stable identity anchor, then attach disease evidence before program review.
Potassium voltage-gated channel subfamily KQT member 1
Review this target as Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK), mapped to UniProt P51787. ChEMBL maps the protein component as Potassium voltage-gated channel subfamily KQT member 1. Sequence length is 676 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) as ChEMBL target CHEMBL2221347, mapped to UniProt P51787. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) is the right protein anchor across sources, using UniProt P51787 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P51787 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Potassium voltage-gated channel subfamily KQT member 1 |
| UniProt Accession | P51787 |
| Component Type | Protein |
| Sequence Length | 676 aa |
Potassium voltage-gated channel subfamily KQT member 1
Review this target as Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK), mapped to UniProt P51787. ChEMBL maps the protein component as Potassium voltage-gated channel subfamily KQT member 1. Sequence length is 676 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL42205 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL124454 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL298475 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL124308 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL340910 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL125307 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL127885 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL340236 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL340025 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL4065169 | 6.1 | IC50 | 790.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 63 | 55 | 4.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 21 | 1 | 6.9 |
| cell-based format | 12 | 18 | 5.8 |
| assay format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 1 | 6.1 |
| protein complex format | 1 | 0 | — |