Caspase-4 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P49662. Use UniProt P49662 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49662 as the stable identity anchor, then attach disease evidence before program review.
Caspase-4
Review this target as Caspase-4, mapped to UniProt P49662. Sequence length is 377 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Caspase-4 as ChEMBL target CHEMBL2226, mapped to UniProt P49662. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Caspase-4 is the right protein anchor across sources, using UniProt P49662 as the stable mapping.
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| Preferred Name | Caspase-4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P49662 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Caspase-4 |
| UniProt Accession | P49662 |
| Component Type | Protein |
| Sequence Length | 377 aa |
Caspase-4
Review this target as Caspase-4, mapped to UniProt P49662. Sequence length is 377 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3949842 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL3949842 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL5715921 | 7.09 | IC50 | 81.7 | Preclinical |
| CHEMBL5715925 | 7.08 | IC50 | 84.0 | Preclinical |
| CHEMBL2323966 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL3970645 | 6.92 | Ki | 119.0 | Preclinical |
| CHEMBL3941088 | 6.83 | Ki | 148.0 | Preclinical |
| CHEMBL2324340 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL3905486 | 6.68 | Ki | 207.0 | Preclinical |
| CHEMBL3984293 | 6.67 | Ki | 215.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 22 | 5.2 |
| assay format | 3 | 15 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 7.1 |