Cytochrome P450 1A1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P04798. Use UniProt P04798 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04798 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 1A1
Review this target as Cytochrome P450 1A1, mapped to UniProt P04798. Sequence length is 512 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 1A1 as ChEMBL target CHEMBL2231, mapped to UniProt P04798. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 1A1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P04798 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 1A1 |
| UniProt Accession | P04798 |
| Component Type | Protein |
| Sequence Length | 512 aa |
Cytochrome P450 1A1
Review this target as Cytochrome P450 1A1, mapped to UniProt P04798. Sequence length is 512 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4467401 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4798651 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL4759437 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL5566974 | 8.79 | IC50 | 1.63 | Preclinical |
| CHEMBL3132932 | 8.75 | IC50 | 1.77 | Preclinical |
| CHEMBL3422338 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL4799247 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL4457289 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4781932 | 8.51 | IC50 | 3.1 | Preclinical |
| CHEMBL3220150 | 8.48 | IC50 | 3.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 144 | 310 | 6.8 |
| assay format | 32 | 84 | 6.4 |
| microsome format | 15 | 5 | 5.9 |
| cell-based format | 14 | 25 | 5.8 |
| cell membrane format | 5 | 36 | 6.0 |
| tissue-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 19 | 44 | 5.9 |
| assay format | 11 | 37 | 5.8 |
| cell membrane format | 5 | 18 | 6.7 |
| single protein format | 3 | 11 | 6.2 |
| tissue-based format | 1 | 0 | — |