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Target Snapshot

CHEMBL2241 Target Snapshot

Glutathione S-transferase A2 · SINGLE PROTEIN · Homo sapiens

39Compounds
5Assays
0Approved Drugs
36.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P09210. Use UniProt P09210 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P09210 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutathione S-transferase A2 as ChEMBL target CHEMBL2241, mapped to UniProt P09210. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutathione S-transferase A2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2241
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P09210
Glutathione S-transferase A2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutathione S-transferase A2 is the right protein anchor across sources, using UniProt P09210 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutathione S-transferase A2
UniProt AccessionP09210
Component TypeProtein
Sequence Length222 aa

Glutathione S-transferase A2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glutathione S-transferase A2, mapped to UniProt P09210. Sequence length is 222 aa.

Mapped IDP09210
Review nameGlutathione S-transferase A2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5036.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL405395 8.3 IC50 5.0 Preclinical
CHEMBL174893 5.39 IC50 4100.0 Preclinical
CHEMBL359933 5.08 IC50 8400.0 Preclinical
CHEMBL177327 4.72 IC50 19100.0 Preclinical
CHEMBL369465 4.5 IC50 31900.0 Preclinical
CHEMBL1938640 4.48 IC50 33100.0 Preclinical
CHEMBL1938641 4.42 IC50 37800.0 Preclinical
CHEMBL441308 4.39 IC50 41000.0 Preclinical
CHEMBL176294 4.32 IC50 48000.0 Preclinical
CHEMBL174957 4.18 IC50 66000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
19
Tested Compounds
2
Assay Types
Binding — 4 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 19 4.6
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine