4-hydroxy-3-methylbut-2-enyl diphosphate reductase · SINGLE PROTEIN · Aquifex aeolicus (strain VF5)
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As of 2026-09-14Protein identity stays anchored to UniProt O67625. Use UniProt O67625 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O67625 as the stable identity anchor, then attach disease evidence before program review.
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Review this target as 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, mapped to UniProt O67625. Sequence length is 289 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 4-hydroxy-3-methylbut-2-enyl diphosphate reductase as ChEMBL target CHEMBL2242741, mapped to UniProt O67625. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Aquifex aeolicus (strain VF5) |
| UniProt | O67625 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| UniProt Accession | O67625 |
| Component Type | Protein |
| Sequence Length | 289 aa |
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Review this target as 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, mapped to UniProt O67625. Sequence length is 289 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2251810 | 7.22 | Ki | 60.0 | Preclinical |
| CHEMBL2251810 | 6.35 | IC50 | 450.0 | Preclinical |
| CHEMBL2251821 | 5.92 | Ki | 1200.0 | Preclinical |
| CHEMBL2251811 | 5.19 | IC50 | 6500.0 | Preclinical |
| CHEMBL2251809 | 5.17 | IC50 | 6700.0 | Preclinical |
| CHEMBL2251821 | 5.04 | IC50 | 9100.0 | Preclinical |
| CHEMBL2251812 | 4.58 | IC50 | 26000.0 | Preclinical |
| CHEMBL2251817 | 4.42 | IC50 | 38000.0 | Preclinical |
| CHEMBL2251814 | 4.28 | IC50 | 53000.0 | Preclinical |
| CHEMBL55557 | 4.17 | IC50 | 67000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 15 | 5.2 |