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Target Snapshot

CHEMBL2243 Target Snapshot

Fatty-acid amide hydrolase 1 · SINGLE PROTEIN · Homo sapiens

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3,015Compounds
360Assays
2Approved Drugs
3,498.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Fatty-acid amide hydrolase 1 shows approved-linked disease relevance led by arthritis. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O00519. Start with arthritis, then reuse UniProt O00519 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with arthritis, then reuse UniProt O00519 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
arthritis

Fatty-acid amide hydrolase 1 shows approved-linked disease relevance led by arthritis. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with arthritis because it currently carries approved-linked support. Linked drugs include ACETAMINOPHEN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fatty-acid amide hydrolase 1 as ChEMBL target CHEMBL2243, mapped to UniProt O00519. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fatty-acid amide hydrolase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2243
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O00519
Fatty-acid amide hydrolase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fatty-acid amide hydrolase 1 is the right protein anchor across sources, using UniProt O00519 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why arthritis is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameFatty-acid amide hydrolase 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO00519
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFatty-acid amide hydrolase 1
UniProt AccessionO00519
Component TypeProtein
Sequence Length579 aa

Fatty-acid amide hydrolase 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Fatty-acid amide hydrolase 1, mapped to UniProt O00519. Sequence length is 579 aa.

Mapped IDO00519
Review nameFatty-acid amide hydrolase 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Fatty-acid amide hydrolase 1 shows approved-linked disease relevance led by arthritis. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
arthritis
1 linked drug · 1 direct · 1 efficacy
Linked drugACETAMINOPHEN
Approved-linked Approved
Back pain
1 linked drug · 1 direct · 1 efficacy
Linked drugACETAMINOPHEN
Approved-linked Approved
common cold
1 linked drug · 1 direct · 1 efficacy
Linked drugACETAMINOPHEN
Approved-linked Approved
Dysmenorrhea
1 linked drug · 1 direct · 1 efficacy
Linked drugACETAMINOPHEN
Approved-linked Approved
Fever
1 linked drug · 1 direct · 1 efficacy
Linked drugACETAMINOPHEN
Approved-linked Approved
Headache
1 linked drug · 1 direct · 1 efficacy
Linked drugACETAMINOPHEN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with arthritis because it currently carries approved-linked support. Linked drugs include ACETAMINOPHEN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasearthritis
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Approved
5
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC503,033.0
KI460.0
EC504.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3798535 11.0 IC50 0.01 Preclinical
CHEMBL3797772 11.0 IC50 0.01 Preclinical
CHEMBL3798476 10.89 Ki 0.0128 Preclinical
CHEMBL3798355 10.83 Ki 0.0147 Preclinical
CHEMBL3800599 10.73 Ki 0.0185 Preclinical
CHEMBL3799008 10.73 Ki 0.0185 Preclinical
CHEMBL3799516 10.73 Ki 0.0185 Preclinical
CHEMBL3798487 10.7 IC50 0.02 Preclinical
CHEMBL3113272 10.6 IC50 0.025 Preclinical
CHEMBL3797635 10.52 IC50 0.03 Preclinical
Distribution

pChEMBL Value Distribution

332
5.0
260
5.5
308
6.0
311
6.5
355
7.0
407
7.5
313
8.0
187
8.5
111
9.0
27
9.5
pChEMBL
Assay Landscape

Assay Landscape

360
Total Assays
2,162
Tested Compounds
2
Assay Types
Binding — 349 assays, 2,162 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 196 988 6.8
cell-based format 89 622 7.1
assay format 54 552 6.9
tissue-based format 6 0 —
cell membrane format 4 0 —
ADME — 11 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 4 5.9
single protein format 5 0 —
subcellular format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine