Tyrosine-protein kinase Blk · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P51451. Use UniProt P51451 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51451 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase Blk
Review this target as Tyrosine-protein kinase Blk, mapped to UniProt P51451. Sequence length is 505 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase Blk as ChEMBL target CHEMBL2250, mapped to UniProt P51451. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein kinase Blk |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51451 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase Blk |
| UniProt Accession | P51451 |
| Component Type | Protein |
| Sequence Length | 505 aa |
Tyrosine-protein kinase Blk
Review this target as Tyrosine-protein kinase Blk, mapped to UniProt P51451. Sequence length is 505 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1873475 | 10.0 | IC50 | 0.1 | Approved |
| CHEMBL4211949 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3647967 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5416410 | 9.68 | Kd | 0.21 | Approved |
| CHEMBL5189379 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL1873475 | 9.25 | Kd | 0.56 | Approved |
| CHEMBL4464404 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL1994938 | 9.1 | Ki | 0.7943 | Preclinical |
| CHEMBL249097 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL1988717 | 9.0 | Ki | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 350 | 200 | 7.0 |
| assay format | 58 | 35 | 6.9 |
| cell-based format | 45 | 48 | 7.1 |
| subcellular format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |
| single protein format | 2 | 2 | 9.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 224 | 6.9 |
| cell-based format | 1 | 1 | 6.4 |