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Target Snapshot

CHEMBL2259 Target Snapshot

Vitamin D-binding protein · SINGLE PROTEIN · Homo sapiens

37Compounds
13Assays
1Approved Drugs
1.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P02774. Use UniProt P02774 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02774 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Vitamin D-binding protein as ChEMBL target CHEMBL2259, mapped to UniProt P02774. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Vitamin D-binding protein
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2259
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P02774
Vitamin D-binding protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Vitamin D-binding protein is the right protein anchor across sources, using UniProt P02774 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVitamin D-binding protein
UniProt AccessionP02774
Component TypeProtein
Sequence Length474 aa

Vitamin D-binding protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Vitamin D-binding protein, mapped to UniProt P02774. Sequence length is 474 aa.

Mapped IDP02774
Review nameVitamin D-binding protein
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL846 7.62 Kd 24.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CALCITRIOL
CHEMBL846
Approved 1978
Assay Landscape

Assay Landscape

13
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 13 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 1 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine