Adenosine receptor A1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Adenosine receptor A1 shows late clinical disease relevance led by congestive heart failure. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P30542. Start with congestive heart failure, then reuse UniProt P30542 as the stable protein anchor across project notes and exports.
Start with congestive heart failure, then reuse UniProt P30542 as the stable protein anchor across project notes and exports.
Adenosine receptor A1 shows late clinical disease relevance led by congestive heart failure. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with congestive heart failure because it currently carries late clinical support. Linked drugs include DERENOFYLLINE, ROLOFYLLINE, TONAPOFYLLINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAdenosine receptor A1
Review this target as Adenosine receptor A1, mapped to UniProt P30542. Sequence length is 326 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenosine receptor A1 as ChEMBL target CHEMBL226, mapped to UniProt P30542. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Adenosine receptor A1 is the right protein anchor across sources, using UniProt P30542 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why congestive heart failure is currently framed as late clinical support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Adenosine receptor A1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P30542 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A1 |
| UniProt Accession | P30542 |
| Component Type | Protein |
| Sequence Length | 326 aa |
Adenosine receptor A1
Review this target as Adenosine receptor A1, mapped to UniProt P30542. Sequence length is 326 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Adenosine receptor A1 shows late clinical disease relevance led by congestive heart failure. 5 more disease programs remain visible in the same review block.
Start review with congestive heart failure because it currently carries late clinical support. Linked drugs include DERENOFYLLINE, ROLOFYLLINE, TONAPOFYLLINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3770679 | 10.53 | IC50 | 0.02951 | Preclinical |
| CHEMBL1090577 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3917744 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL3962333 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL5177144 | 10.29 | Ki | 0.051 | Preclinical |
| CHEMBL3961898 | 10.22 | EC50 | 0.06 | Preclinical |
| CHEMBL5171044 | 10.12 | Ki | 0.076 | Preclinical |
| CHEMBL3966416 | 10.1 | EC50 | 0.08 | Preclinical |
| CHEMBL1093271 | 10.02 | Ki | 0.096 | Preclinical |
| CHEMBL2419137 | 10.0 | Ki | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 774 | 3,742 | 6.7 |
| single protein format | 367 | 581 | 6.8 |
| cell membrane format | 71 | 335 | 7.0 |
| assay format | 35 | 252 | 7.3 |
| tissue-based format | 1 | 2 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 234 | 483 | 7.5 |
| assay format | 41 | 208 | 7.0 |
| cell membrane format | 6 | 15 | 8.2 |
| single protein format | 2 | 8 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 17 | 7.0 |
| single protein format | 2 | 22 | 7.5 |