Use UniProt P31323 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2270 Target Snapshot
cAMP-dependent protein kinase type II-beta regulatory subunit · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P31323. Use UniProt P31323 as the stable identity anchor, then attach disease evidence before program review.
cAMP-dependent protein kinase type II-beta regulatory subunit
Review this target as cAMP-dependent protein kinase type II-beta regulatory subunit, mapped to UniProt P31323. Sequence length is 418 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats cAMP-dependent protein kinase type II-beta regulatory subunit as ChEMBL target CHEMBL2270, mapped to UniProt P31323. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether cAMP-dependent protein kinase type II-beta regulatory subunit is the right protein anchor across sources, using UniProt P31323 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | cAMP-dependent protein kinase type II-beta regulatory subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P31323 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cAMP-dependent protein kinase type II-beta regulatory subunit |
| UniProt Accession | P31323 |
| Component Type | Protein |
| Sequence Length | 418 aa |
cAMP-dependent protein kinase type II-beta regulatory subunit
How to read this target
Review this target as cAMP-dependent protein kinase type II-beta regulatory subunit, mapped to UniProt P31323. Sequence length is 418 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4203735 | 7.12 | Kd | 75.0 | Preclinical |
| CHEMBL4204708 | 6.91 | Kd | 124.0 | Preclinical |
| CHEMBL4211508 | 6.88 | Kd | 131.0 | Preclinical |
| CHEMBL4207455 | 6.83 | Kd | 147.0 | Preclinical |
| CHEMBL4215761 | 6.82 | Kd | 152.0 | Preclinical |
| CHEMBL4204281 | 6.59 | Kd | 257.0 | Preclinical |
| CHEMBL4205523 | 6.25 | Kd | 557.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 1 assays, 7 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 7 | 6.8 |