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Target Snapshot

CHEMBL2270 Target Snapshot

cAMP-dependent protein kinase type II-beta regulatory subunit · SINGLE PROTEIN · Homo sapiens

13Compounds
1Assays
0Approved Drugs
13.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P31323. Use UniProt P31323 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P31323 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats cAMP-dependent protein kinase type II-beta regulatory subunit as ChEMBL target CHEMBL2270, mapped to UniProt P31323. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
cAMP-dependent protein kinase type II-beta regulatory subunit
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2270
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P31323
cAMP-dependent protein kinase type II-beta regulatory subunit
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether cAMP-dependent protein kinase type II-beta regulatory subunit is the right protein anchor across sources, using UniProt P31323 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelcAMP-dependent protein kinase type II-beta regulatory subunit
UniProt AccessionP31323
Component TypeProtein
Sequence Length418 aa

cAMP-dependent protein kinase type II-beta regulatory subunit

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as cAMP-dependent protein kinase type II-beta regulatory subunit, mapped to UniProt P31323. Sequence length is 418 aa.

Mapped IDP31323
Review namecAMP-dependent protein kinase type II-beta regulatory subunit
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

KD13.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4203735 7.12 Kd 75.0 Preclinical
CHEMBL4204708 6.91 Kd 124.0 Preclinical
CHEMBL4211508 6.88 Kd 131.0 Preclinical
CHEMBL4207455 6.83 Kd 147.0 Preclinical
CHEMBL4215761 6.82 Kd 152.0 Preclinical
CHEMBL4204281 6.59 Kd 257.0 Preclinical
CHEMBL4205523 6.25 Kd 557.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
5
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
7
Tested Compounds
1
Assay Types
Binding — 1 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 7 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine