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Target Snapshot

CHEMBL2274 Target Snapshot

Sphingosine 1-phosphate receptor 5 · SINGLE PROTEIN · Homo sapiens

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749Compounds
135Assays
5Approved Drugs
870.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Sphingosine 1-phosphate receptor 5 shows approved-linked disease relevance led by ulcerative colitis. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9H228. Start with ulcerative colitis, then reuse UniProt Q9H228 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with ulcerative colitis, then reuse UniProt Q9H228 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
ulcerative colitis

Sphingosine 1-phosphate receptor 5 shows approved-linked disease relevance led by ulcerative colitis. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with ulcerative colitis because it currently carries approved-linked support. Linked drugs include ETRASIMOD ARGININE, OZANIMOD. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sphingosine 1-phosphate receptor 5 as ChEMBL target CHEMBL2274, mapped to UniProt Q9H228. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sphingosine 1-phosphate receptor 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2274
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9H228
Sphingosine 1-phosphate receptor 5
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sphingosine 1-phosphate receptor 5 is the right protein anchor across sources, using UniProt Q9H228 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why ulcerative colitis is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSphingosine 1-phosphate receptor 5
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9H228
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSphingosine 1-phosphate receptor 5
UniProt AccessionQ9H228
Component TypeProtein
Sequence Length398 aa

Sphingosine 1-phosphate receptor 5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Sphingosine 1-phosphate receptor 5, mapped to UniProt Q9H228. Sequence length is 398 aa.

Mapped IDQ9H228
Review nameSphingosine 1-phosphate receptor 5
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Sphingosine 1-phosphate receptor 5 shows approved-linked disease relevance led by ulcerative colitis. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
ulcerative colitis
2 linked drugs · 2 direct · 2 efficacy
Linked drugETRASIMOD ARGININE
Linked drugOZANIMOD
Late clinical Phase III
Crohn's disease
1 linked drug · 1 direct · 1 efficacy
Linked drugOZANIMOD
Late clinical Phase III
multiple sclerosis
1 linked drug · 1 direct · 1 efficacy
Linked drugOZANIMOD
Late clinical Phase III
relapsing-remitting multiple sclerosis
1 linked drug · 1 direct · 1 efficacy
Linked drugOZANIMOD
Clinical signal Phase II
COVID-19
1 linked drug · 1 direct · 1 efficacy
Linked drugOZANIMOD
Clinical signal Phase I
liver disease
1 linked drug · 1 direct · 1 efficacy
Linked drugOZANIMOD
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with ulcerative colitis because it currently carries approved-linked support. Linked drugs include ETRASIMOD ARGININE, OZANIMOD. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseulcerative colitis
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

5
Approved
Assay Mix

Activity Type Distribution

IC50338.0
KI5.0
EC50519.0
KD8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4787458 10.52 EC50 0.03 Preclinical
CHEMBL4754965 10.2 EC50 0.063 Preclinical
CHEMBL4748198 10.0 EC50 0.1 Preclinical
CHEMBL4798593 10.0 EC50 0.1 Preclinical
CHEMBL225155 9.7 EC50 0.2 Preclinical
CHEMBL4784199 9.57 EC50 0.27 Preclinical
CHEMBL314854 9.52 EC50 0.3 Approved
CHEMBL366208 9.52 EC50 0.3 Preclinical
CHEMBL4787458 9.52 Ki 0.3 Preclinical
CHEMBL381872 9.52 IC50 0.3 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
39
5.5
60
6.0
86
6.5
114
7.0
134
7.5
88
8.0
42
8.5
37
9.0
6
9.5
pChEMBL
Approved Drugs

Approved Drugs

ETRASIMOD
CHEMBL3358920
Approved 2023
Properties Compare Identifier
OZANIMOD
CHEMBL3707247
Approved 2020
Properties Compare Identifier
SIPONIMOD
CHEMBL2336071
Approved 2019
Properties Compare Identifier
FINGOLIMOD
CHEMBL314854
Approved 2010
Properties Compare Identifier
Assay Landscape

Assay Landscape

135
Total Assays
349
Tested Compounds
2
Assay Types
Functional — 68 assays, 215 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 43 158 7.5
assay format 19 48 7.0
cell membrane format 4 6 8.5
single protein format 2 3 8.6
Binding — 67 assays, 349 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 32 67 6.8
cell-based format 31 251 7.4
assay format 2 4 7.6
cell membrane format 2 27 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine