Lysosomal acid glucosylceramidase · SINGLE PROTEIN · Mus musculus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-15Protein identity stays anchored to UniProt P17439. Use UniProt P17439 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P17439 as the stable identity anchor, then attach disease evidence before program review.
Lysosomal acid glucosylceramidase
Review this target as Lysosomal acid glucosylceramidase, mapped to UniProt P17439. Sequence length is 515 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysosomal acid glucosylceramidase as ChEMBL target CHEMBL2278, mapped to UniProt P17439. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysosomal acid glucosylceramidase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P17439 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysosomal acid glucosylceramidase |
| UniProt Accession | P17439 |
| Component Type | Protein |
| Sequence Length | 515 aa |
Lysosomal acid glucosylceramidase
Review this target as Lysosomal acid glucosylceramidase, mapped to UniProt P17439. Sequence length is 515 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL422734 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL176679 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL170431 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL3350141 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL354193 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL369361 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL426933 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL3350143 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL2115067 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL3350142 | 6.16 | IC50 | 700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 16 | 6.1 |
| tissue-based format | 4 | 3 | 5.0 |
| assay format | 2 | 0 | — |