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Target Snapshot

CHEMBL2285357 Target Snapshot

Glutamine synthetase, chloroplastic · SINGLE PROTEIN · Zea mays

24Compounds
4Assays
0Approved Drugs
44.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt P25462. Use UniProt P25462 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P25462 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutamine synthetase, chloroplastic as ChEMBL target CHEMBL2285357, mapped to UniProt P25462. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutamine synthetase, chloroplastic
SINGLE PROTEIN · Zea mays
As of 2026-09-15
ChEMBL target ID
CHEMBL2285357
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
P25462
Glutamine synthetase, chloroplastic
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutamine synthetase, chloroplastic is the right protein anchor across sources, using UniProt P25462 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutamine synthetase, chloroplastic
UniProt AccessionP25462
Component TypeProtein
Sequence Length423 aa

Glutamine synthetase, chloroplastic

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glutamine synthetase, chloroplastic, mapped to UniProt P25462. Sequence length is 423 aa.

Mapped IDP25462
Review nameGlutamine synthetase, chloroplastic
OrganismZea mays
Assay Mix

Activity Type Distribution

IC5040.0
KI4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL55518 5.19 Ki 6400.0 Preclinical
CHEMBL55518 5.12 IC50 7600.0 Preclinical
CHEMBL2252809 4.89 IC50 12793.81 Preclinical
CHEMBL2252811 4.82 IC50 14996.85 Preclinical
CHEMBL2440579 4.68 IC50 20989.4 Preclinical
CHEMBL191613 4.67 IC50 21183.61 Preclinical
CHEMBL2440433 4.5 IC50 31900.0 Preclinical
CHEMBL2252810 4.41 IC50 39174.19 Preclinical
CHEMBL2252814 4.28 Ki 53000.0 Preclinical
CHEMBL2252814 4.25 IC50 55975.76 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 4 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 16 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine