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Evidence Snapshot

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

CHEMBL2288 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:21:21Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2288
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 as ChEMBL target CHEMBL2288, mapped to UniProt Q13526. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2288
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q13526
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 matters

As of 2026-09-13

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is reviewed as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (UniProt Q13526); the current evidence base includes 4 approved drugs, 36317 compounds, and 160 assays, with lead potency reaching pChEMBL 8.9.

Protein context
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Sequence length is 163 aa.

Review this target as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, mapped to UniProt Q13526. Sequence length is 163 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q13526 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 4 approved drugs, 36317 compounds, and 160 assays for this target. The dominant activity type is IC50. CHEMBL219531 is the current potency anchor at pChEMBL 8.9.

Use CHEMBL219531 as the tractability anchor when discussing potency (pChEMBL 8.9).

Activity source · ChEMBL 36 via Core Engine
4 approved pChEMBL 8.9
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q13526, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

36317
Total Compounds
160
Total Assays
4
Approved Drugs
IC50: 469.0, KI: 130.0, EC50: 2.0, KD: 133.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL219531
 8.9 Ki —
No preferred name
CHEMBL5395865
 8.9 Ki —
No preferred name
CHEMBL438271
 8.3 Ki —
No preferred name
CHEMBL585917
 8.2 IC50 —
No preferred name
CHEMBL1090715
 8.2 Ki —

Approved Drugs

Structure Compound First Approval
TRETINOIN
CHEMBL38
 1971
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:21:21Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2288