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Target Snapshot

CHEMBL2295561 Target Snapshot

Lactoperoxidase · SINGLE PROTEIN · Bos taurus

43Compounds
9Assays
2Approved Drugs
30.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P80025. Use UniProt P80025 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P80025 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lactoperoxidase as ChEMBL target CHEMBL2295561, mapped to UniProt P80025. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lactoperoxidase
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL2295561
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P80025
Lactoperoxidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lactoperoxidase is the right protein anchor across sources, using UniProt P80025 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLactoperoxidase
UniProt AccessionP80025
Component TypeProtein
Sequence Length712 aa

Lactoperoxidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lactoperoxidase, mapped to UniProt P80025. Sequence length is 712 aa.

Mapped IDP80025
Review nameLactoperoxidase
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5030.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL251689 6.1 IC50 800.0 Preclinical
CHEMBL276832 5.92 IC50 1200.0 Approved
CHEMBL581893 5.5 IC50 3200.0 Preclinical
CHEMBL4080413 5.41 IC50 3900.0 Preclinical
CHEMBL2299190 5.29 IC50 5100.0 Preclinical
CHEMBL2299191 5.26 IC50 5500.0 Preclinical
CHEMBL2299192 5.21 IC50 6200.0 Preclinical
CHEMBL50 5.21 IC50 6100.0 Clinical
CHEMBL1515 5.08 IC50 8400.0 Approved
CHEMBL2299193 5.08 IC50 8400.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
2
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
21
Tested Compounds
1
Assay Types
Binding — 9 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 21 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine