Estrogen receptor · PROTEIN FAMILY · Ovis aries
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P49885. Use UniProt P49885 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49885 as the stable identity anchor, then attach disease evidence before program review.
Estrogen receptor
Review this target as Estrogen receptor, mapped to UniProt P49885. Sequence length is 111 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Estrogen receptor as ChEMBL target CHEMBL2304421, mapped to UniProt P49885. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Estrogen receptor is the right protein anchor across sources, using UniProt P49885 as the stable mapping.
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| Preferred Name | Estrogen receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Ovis aries |
| UniProt | P49885 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Estrogen receptor |
| UniProt Accession | P49885 |
| Component Type | Protein |
| Sequence Length | 111 aa |
Estrogen receptor
Review this target as Estrogen receptor, mapped to UniProt P49885. Sequence length is 111 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL414213 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL1628077 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL1627886 | 7.28 | IC50 | 53.0 | Preclinical |
| CHEMBL462576 | 6.31 | Kd | 490.0 | Preclinical |
| CHEMBL28 | 6.18 | Kd | 660.0 | Preclinical |
| CHEMBL7855 | 6.06 | Kd | 880.0 | Preclinical |
| CHEMBL8020 | 5.96 | Kd | 1100.0 | Preclinical |
| CHEMBL1627885 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL7970 | 5.4 | Kd | 4000.0 | Preclinical |
| CHEMBL8145 | 5.23 | Kd | 5900.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 40 | 14 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 0 | — |
| tissue-based format | 1 | 0 | — |