Procathepsin L · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P07154. Use UniProt P07154 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07154 as the stable identity anchor, then attach disease evidence before program review.
Procathepsin L
Review this target as Procathepsin L, mapped to UniProt P07154. Sequence length is 334 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Procathepsin L as ChEMBL target CHEMBL2305, mapped to UniProt P07154. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Procathepsin L is the right protein anchor across sources, using UniProt P07154 as the stable mapping.
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| Preferred Name | Procathepsin L |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P07154 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Procathepsin L |
| UniProt Accession | P07154 |
| Component Type | Protein |
| Sequence Length | 334 aa |
Procathepsin L
Review this target as Procathepsin L, mapped to UniProt P07154. Sequence length is 334 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL114410 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL326093 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL117928 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL113706 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL116041 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL323638 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL115734 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL222649 | 8.39 | IC50 | 4.1 | Preclinical |
| CHEMBL323637 | 8.02 | IC50 | 9.6 | Preclinical |
| CHEMBL443319 | 7.32 | IC50 | 48.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 16 | 7.2 |
| assay format | 1 | 9 | 6.7 |
| tissue-based format | 1 | 0 | — |