Use UniProt Q09470 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2309 Target Snapshot
Potassium voltage-gated channel subfamily A member 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q09470. Use UniProt Q09470 as the stable identity anchor, then attach disease evidence before program review.
Potassium voltage-gated channel subfamily A member 1
Review this target as Potassium voltage-gated channel subfamily A member 1, mapped to UniProt Q09470. Sequence length is 495 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Potassium voltage-gated channel subfamily A member 1 as ChEMBL target CHEMBL2309, mapped to UniProt Q09470. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Potassium voltage-gated channel subfamily A member 1 is the right protein anchor across sources, using UniProt Q09470 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | Potassium voltage-gated channel subfamily A member 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q09470 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Potassium voltage-gated channel subfamily A member 1 |
| UniProt Accession | Q09470 |
| Component Type | Protein |
| Sequence Length | 495 aa |
Potassium voltage-gated channel subfamily A member 1
How to read this target
Review this target as Potassium voltage-gated channel subfamily A member 1, mapped to UniProt Q09470. Sequence length is 495 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3609249 | 10.99 | IC50 | 0.0102 | Preclinical |
| CHEMBL3609244 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL3609086 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL3608998 | 10.96 | IC50 | 0.011 | Preclinical |
| CHEMBL3609093 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL3609028 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL3609089 | 10.82 | IC50 | 0.015 | Preclinical |
| CHEMBL3609046 | 10.81 | IC50 | 0.0154 | Preclinical |
| CHEMBL3609247 | 10.8 | IC50 | 0.0157 | Preclinical |
| CHEMBL3608317 | 10.76 | IC50 | 0.0172 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 27 assays, 143 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 22 | 134 | 9.4 |
| single protein format | 5 | 9 | 5.5 |
Functional — 6 assays, 6 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 6 | 6 | 5.3 |