D-3-phosphoglycerate dehydrogenase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O43175. Use UniProt O43175 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O43175 as the stable identity anchor, then attach disease evidence before program review.
D-3-phosphoglycerate dehydrogenase
Review this target as D-3-phosphoglycerate dehydrogenase, mapped to UniProt O43175. Sequence length is 533 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats D-3-phosphoglycerate dehydrogenase as ChEMBL target CHEMBL2311243, mapped to UniProt O43175. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether D-3-phosphoglycerate dehydrogenase is the right protein anchor across sources, using UniProt O43175 as the stable mapping.
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| Preferred Name | D-3-phosphoglycerate dehydrogenase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O43175 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D-3-phosphoglycerate dehydrogenase |
| UniProt Accession | O43175 |
| Component Type | Protein |
| Sequence Length | 533 aa |
D-3-phosphoglycerate dehydrogenase
Review this target as D-3-phosphoglycerate dehydrogenase, mapped to UniProt O43175. Sequence length is 533 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4541133 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4536737 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL4584313 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL4436264 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4518579 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL4467246 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4515492 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4520837 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4527607 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4579388 | 8.48 | IC50 | 3.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 62 | 486 | 5.9 |
| assay format | 29 | 302 | 6.1 |
| cell-based format | 25 | 83 | 6.3 |
| organism-based format | 1 | 10 | 4.5 |
| subcellular format | 1 | 0 | — |