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Target Snapshot

CHEMBL2327 Target Snapshot

Substance-K receptor · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
2,200Compounds
336Assays
60Approved Drugs
3,058.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Substance-K receptor shows late clinical disease relevance led by anxiety. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P21452. Start with anxiety, then reuse UniProt P21452 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with anxiety, then reuse UniProt P21452 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
anxiety

Substance-K receptor shows late clinical disease relevance led by anxiety. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with anxiety because it currently carries late clinical support. Linked drugs include SAREDUTANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Late clinical Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Substance-K receptor as ChEMBL target CHEMBL2327, mapped to UniProt P21452. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Substance-K receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2327
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P21452
Substance-K receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Substance-K receptor is the right protein anchor across sources, using UniProt P21452 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why anxiety is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSubstance-K receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP21452
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSubstance-K receptor
UniProt AccessionP21452
Component TypeProtein
Sequence Length398 aa

Substance-K receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Substance-K receptor, mapped to UniProt P21452. Sequence length is 398 aa.

Mapped IDP21452
Review nameSubstance-K receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Late clinical Open Targets-ready proxy

Substance-K receptor shows late clinical disease relevance led by anxiety. 4 more disease programs remain visible in the same review block.

Late clinical Phase III
anxiety
1 linked drug · 1 direct · 1 efficacy
Linked drugSAREDUTANT
Late clinical Phase III
depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugSAREDUTANT
Late clinical Phase III
irritable bowel syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugIBODUTANT
Late clinical Phase III
major depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugSAREDUTANT
Clinical signal Phase II
Abdominal pain
1 linked drug · 1 direct · 1 efficacy
Linked drugNEPADUTANT
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with anxiety because it currently carries late clinical support. Linked drugs include SAREDUTANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseanxiety
Strongest levelLate clinical
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

60
Approved
10
Phase III
12
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC501,126.0
KI1,900.0
EC505.0
KD27.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL224081 10.6 Ki 0.02512 Preclinical
CHEMBL2112922 10.3 Ki 0.05012 Preclinical
CHEMBL1083850 10.3 Ki 0.05012 Preclinical
CHEMBL436981 10.3 Ki 0.05012 Preclinical
CHEMBL243711 10.28 Ki 0.05248 Preclinical
CHEMBL244362 10.24 Ki 0.05754 Preclinical
CHEMBL395972 10.22 Ki 0.06026 Preclinical
CHEMBL439281 10.2 Ki 0.0631 Preclinical
CHEMBL387506 10.2 Ki 0.0631 Preclinical
CHEMBL266125 10.12 Ki 0.07586 Clinical
Distribution

pChEMBL Value Distribution

95
5.0
75
5.5
67
6.0
95
6.5
102
7.0
125
7.5
160
8.0
130
8.5
103
9.0
60
9.5
pChEMBL
Approved Drugs

Approved Drugs

RITONAVIR
CHEMBL163
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
EBASTINE
CHEMBL305660
Approved 1990
Properties Compare Identifier
ASTEMIZOLE
CHEMBL296419
Approved 1988
Properties Compare Identifier
TERFENADINE
CHEMBL17157
Approved 1985
Properties Compare Identifier
HALOPROGIN
CHEMBL1289
Approved 1982
Properties Compare Identifier
GENTIAN VIOLET
CHEMBL64894
Approved 1982
Properties Compare Identifier
Assay Landscape

Assay Landscape

336
Total Assays
973
Tested Compounds
3
Assay Types
Binding — 317 assays, 973 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 228 419 7.6
cell-based format 81 478 7.6
assay format 6 14 5.4
cell membrane format 2 62 6.0
Functional — 18 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 13 7.1
assay format 6 4 8.0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine