Dihydrofolate reductase · SINGLE PROTEIN · Candida albicans
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As of 2026-09-13Protein identity stays anchored to UniProt P22906. Use UniProt P22906 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22906 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P22906. Sequence length is 192 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL2329, mapped to UniProt P22906. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dihydrofolate reductase is the right protein anchor across sources, using UniProt P22906 as the stable mapping.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Candida albicans |
| UniProt | P22906 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P22906 |
| Component Type | Protein |
| Sequence Length | 192 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P22906. Sequence length is 192 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL170758 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL171305 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL353161 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL173617 | 9.66 | Ki | 0.22 | Preclinical |
| CHEMBL318721 | 9.66 | Ki | 0.22 | Preclinical |
| CHEMBL353621 | 9.64 | Ki | 0.23 | Preclinical |
| CHEMBL30938 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL170654 | 9.48 | Ki | 0.33 | Preclinical |
| CHEMBL170144 | 9.48 | Ki | 0.33 | Preclinical |
| CHEMBL171629 | 9.42 | Ki | 0.38 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 120 | 6.6 |
| assay format | 1 | 82 | 7.0 |