Serine/threonine-protein kinase B-raf · SINGLE PROTEIN · Mus musculus
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As of 2026-09-12Protein identity stays anchored to UniProt P28028. Use UniProt P28028 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28028 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase B-raf
Review this target as Serine/threonine-protein kinase B-raf, mapped to UniProt P28028. Sequence length is 751 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase B-raf as ChEMBL target CHEMBL2331061, mapped to UniProt P28028. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase B-raf |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P28028 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase B-raf |
| UniProt Accession | P28028 |
| Component Type | Protein |
| Sequence Length | 751 aa |
Serine/threonine-protein kinase B-raf
Review this target as Serine/threonine-protein kinase B-raf, mapped to UniProt P28028. Sequence length is 751 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4294787 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL1229517 | 7.52 | IC50 | 30.0 | Approved |
| CHEMBL1079742 | 7.4 | IC50 | 40.0 | Approved |
| CHEMBL4209555 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL4290513 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL553 | 7.22 | IC50 | 60.0 | Approved |
| CHEMBL4277125 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL4206547 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL4208224 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL1336 | 6.89 | IC50 | 130.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 78 | 5.9 |
| cell-based format | 1 | 0 | — |