Alpha-ketoglutarate-dependent dioxygenase FTO · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Alpha-ketoglutarate-dependent dioxygenase FTO shows clinical signal disease relevance led by acute myeloid leukemia. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9C0B1. Start with acute myeloid leukemia, then reuse UniProt Q9C0B1 as the stable protein anchor across project notes and exports.
Start with acute myeloid leukemia, then reuse UniProt Q9C0B1 as the stable protein anchor across project notes and exports.
Alpha-ketoglutarate-dependent dioxygenase FTO shows clinical signal disease relevance led by acute myeloid leukemia. 1 linked drug remains visible in the same block.
Start review with acute myeloid leukemia because it currently carries clinical signal support. Linked drugs include BISANTRENE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAlpha-ketoglutarate-dependent dioxygenase FTO
Review this target as Alpha-ketoglutarate-dependent dioxygenase FTO, mapped to UniProt Q9C0B1. Sequence length is 505 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-ketoglutarate-dependent dioxygenase FTO as ChEMBL target CHEMBL2331065, mapped to UniProt Q9C0B1. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Alpha-ketoglutarate-dependent dioxygenase FTO is the right protein anchor across sources, using UniProt Q9C0B1 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acute myeloid leukemia is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Alpha-ketoglutarate-dependent dioxygenase FTO |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9C0B1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-ketoglutarate-dependent dioxygenase FTO |
| UniProt Accession | Q9C0B1 |
| Component Type | Protein |
| Sequence Length | 505 aa |
Alpha-ketoglutarate-dependent dioxygenase FTO
Review this target as Alpha-ketoglutarate-dependent dioxygenase FTO, mapped to UniProt Q9C0B1. Sequence length is 505 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Alpha-ketoglutarate-dependent dioxygenase FTO shows clinical signal disease relevance led by acute myeloid leukemia.
Start review with acute myeloid leukemia because it currently carries clinical signal support. Linked drugs include BISANTRENE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5196484 | 7.55 | Kd | 28.0 | Preclinical |
| CHEMBL4572939 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL5195767 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL5219846 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL5196484 | 7.06 | IC50 | 87.0 | Preclinical |
| CHEMBL5200892 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL5410889 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL5207866 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL5174419 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL5194680 | 6.57 | IC50 | 270.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 40 | 20 | 5.3 |
| single protein format | 36 | 156 | 5.6 |
| assay format | 20 | 73 | 5.3 |