Caspase-3 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P42574. Use UniProt P42574 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42574 as the stable identity anchor, then attach disease evidence before program review.
Caspase-3
Review this target as Caspase-3, mapped to UniProt P42574. Sequence length is 277 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Caspase-3 as ChEMBL target CHEMBL2334, mapped to UniProt P42574. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Caspase-3 is the right protein anchor across sources, using UniProt P42574 as the stable mapping.
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| Preferred Name | Caspase-3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42574 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Caspase-3 |
| UniProt Accession | P42574 |
| Component Type | Protein |
| Sequence Length | 277 aa |
Caspase-3
Review this target as Caspase-3, mapped to UniProt P42574. Sequence length is 277 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4751195 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL180669 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL213759 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL417149 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5723373 | 9.64 | Ki | 0.23 | Preclinical |
| CHEMBL213759 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL178116 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL456799 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL456799 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5723360 | 9.17 | Ki | 0.68 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 203 | 1,006 | 6.7 |
| cell-based format | 75 | 183 | 6.3 |
| assay format | 28 | 146 | 7.1 |
| biochemical format | 1 | 0 | — |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 13 | 772 | 4.8 |
| cell-based format | 3 | 1 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 4 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |