Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL2336 Target Snapshot

Mitogen-activated protein kinase 14 · SINGLE PROTEIN · Mus musculus

248Compounds
38Assays
0Approved Drugs
237.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P47811. Use UniProt P47811 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P47811 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mitogen-activated protein kinase 14 as ChEMBL target CHEMBL2336, mapped to UniProt P47811. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mitogen-activated protein kinase 14
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2336
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P47811
Mitogen-activated protein kinase 14
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mitogen-activated protein kinase 14 is the right protein anchor across sources, using UniProt P47811 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMitogen-activated protein kinase 14
UniProt AccessionP47811
Component TypeProtein
Sequence Length360 aa

Mitogen-activated protein kinase 14

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mitogen-activated protein kinase 14, mapped to UniProt P47811. Sequence length is 360 aa.

Mapped IDP47811
Review nameMitogen-activated protein kinase 14
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC50197.0
KI5.0
KD35.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL103667 10.34 Kd 0.046 Clinical
CHEMBL336001 10.13 Kd 0.074 Preclinical
CHEMBL143886 10.02 Kd 0.096 Preclinical
CHEMBL143134 10.0 Kd 0.1 Preclinical
CHEMBL344625 9.8 Kd 0.16 Preclinical
CHEMBL104991 9.74 Kd 0.18 Preclinical
CHEMBL318810 9.64 Kd 0.23 Preclinical
CHEMBL344800 9.64 Kd 0.23 Preclinical
CHEMBL2088591 9.48 IC50 0.33 Preclinical
CHEMBL142115 9.4 Kd 0.4 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
8
5.5
28
6.0
18
6.5
35
7.0
42
7.5
35
8.0
12
8.5
11
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

38
Total Assays
221
Tested Compounds
2
Assay Types
Binding — 36 assays, 221 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 29 6.8
single protein format 14 170 7.4
assay format 2 5 6.8
organism-based format 1 17 6.5
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine