Ribosomal protein S6 kinase alpha-3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P51812. Use UniProt P51812 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51812 as the stable identity anchor, then attach disease evidence before program review.
Ribosomal protein S6 kinase alpha-3
Review this target as Ribosomal protein S6 kinase alpha-3, mapped to UniProt P51812. Sequence length is 740 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ribosomal protein S6 kinase alpha-3 as ChEMBL target CHEMBL2345, mapped to UniProt P51812. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ribosomal protein S6 kinase alpha-3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51812 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ribosomal protein S6 kinase alpha-3 |
| UniProt Accession | P51812 |
| Component Type | Protein |
| Sequence Length | 740 aa |
Ribosomal protein S6 kinase alpha-3
Review this target as Ribosomal protein S6 kinase alpha-3, mapped to UniProt P51812. Sequence length is 740 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 10.1 | IC50 | 0.0795 | Preclinical |
| CHEMBL3673622 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3673631 | 9.57 | IC50 | 0.27 | Preclinical |
| CHEMBL4292020 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3673624 | 9.47 | IC50 | 0.34 | Preclinical |
| CHEMBL3673609 | 9.41 | IC50 | 0.39 | Preclinical |
| CHEMBL3702836 | 9.27 | Kd | 0.54 | Preclinical |
| CHEMBL3673603 | 9.11 | IC50 | 0.78 | Preclinical |
| CHEMBL1933280 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL495727 | 9.0 | IC50 | 1.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 444 | 396 | 6.7 |
| cell-based format | 118 | 66 | 6.5 |
| assay format | 76 | 20 | 6.7 |
| subcellular format | 65 | 16 | 5.6 |
| tissue-based format | 3 | 7 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 426 | 6.0 |