Nicotinamide N-methyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P40261. Use UniProt P40261 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P40261 as the stable identity anchor, then attach disease evidence before program review.
Nicotinamide N-methyltransferase
Review this target as Nicotinamide N-methyltransferase, mapped to UniProt P40261. Sequence length is 264 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nicotinamide N-methyltransferase as ChEMBL target CHEMBL2346486, mapped to UniProt P40261. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nicotinamide N-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P40261 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nicotinamide N-methyltransferase |
| UniProt Accession | P40261 |
| Component Type | Protein |
| Sequence Length | 264 aa |
Nicotinamide N-methyltransferase
Review this target as Nicotinamide N-methyltransferase, mapped to UniProt P40261. Sequence length is 264 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4867273 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL4553052 | 9.72 | Ki | 0.1905 | Preclinical |
| CHEMBL4580446 | 9.62 | Ki | 0.2399 | Preclinical |
| CHEMBL4859806 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL4847740 | 9.33 | IC50 | 0.47 | Preclinical |
| CHEMBL4591248 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL4857394 | 9.03 | IC50 | 0.93 | Preclinical |
| CHEMBL4878738 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL5194905 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL5408922 | 8.92 | Ki | 1.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 43 | 76 | 6.3 |
| assay format | 36 | 49 | 6.3 |
| single protein format | 27 | 91 | 6.5 |
| subcellular format | 2 | 0 | — |