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Target Snapshot

CHEMBL2354204 Target Snapshot

Bacterial penicillin-binding protein · PROTEIN FAMILY · Bacteria

1Compounds
1Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Bacterial penicillin-binding protein shows approved-linked disease relevance led by bacterial disease. 5 more disease programs remain visible in the same review block. 38 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P24228. Start with bacterial disease, then reuse UniProt P24228 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with bacterial disease, then reuse UniProt P24228 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 38 linked drugs
Open source guide
Disease program
bacterial disease

Bacterial penicillin-binding protein shows approved-linked disease relevance led by bacterial disease. 5 more disease programs remain visible in the same review block. 38 linked drugs remain visible in the same block.

Start review with bacterial disease because it currently carries approved-linked support. Linked drugs include AMOXICILLIN, AMPICILLIN, AZTREONAM, CEFACLOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 38 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bacterial penicillin-binding protein as ChEMBL target CHEMBL2354204, mapped to UniProt P24228. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bacterial penicillin-binding protein
PROTEIN FAMILY · Bacteria
As of 2026-09-13
ChEMBL target ID
CHEMBL2354204
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P24228
D-alanyl-D-alanine carboxypeptidase DacB
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Bacterial penicillin-binding protein is the right protein anchor across sources, using UniProt P24228 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why bacterial disease is currently framed as approved-linked support. It currently carries 38 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelD-alanyl-D-alanine carboxypeptidase DacB
UniProt AccessionP24228
Component TypeProtein
Sequence Length477 aa

D-alanyl-D-alanine carboxypeptidase DacB

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Bacterial penicillin-binding protein, mapped to UniProt P24228. ChEMBL maps the protein component as D-alanyl-D-alanine carboxypeptidase DacB. Sequence length is 477 aa.

Mapped IDP24228
Review nameBacterial penicillin-binding protein
OrganismBacteria
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Bacterial penicillin-binding protein shows approved-linked disease relevance led by bacterial disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
bacterial disease
38 linked drugs · 38 direct · 38 efficacy
Linked drugAMOXICILLIN
Linked drugAMPICILLIN
Linked drugAZTREONAM
Linked drugCEFACLOR
Approved-linked Approved
osteomyelitis
38 linked drugs · 38 direct · 38 efficacy
Linked drugAMOXICILLIN
Linked drugAMPICILLIN
Linked drugAMPICILLIN SODIUM
Linked drugAZTREONAM
Approved-linked Approved
infection
37 linked drugs · 37 direct · 37 efficacy
Linked drugAMOXICILLIN
Linked drugAMPICILLIN
Linked drugAMPICILLIN SODIUM
Linked drugAZTREONAM
Approved-linked Approved
urinary tract infection
24 linked drugs · 24 direct · 24 efficacy
Linked drugAMOXICILLIN
Linked drugAZTREONAM
Linked drugCEFACLOR
Linked drugCEFDITOREN PIVOXIL
Approved-linked Approved
pneumonia
23 linked drugs · 23 direct · 23 efficacy
Linked drugAMOXICILLIN
Linked drugAZTREONAM
Linked drugCEFACLOR
Linked drugCEFDINIR
Approved-linked Approved
bacterial pneumonia
11 linked drugs · 11 direct · 11 efficacy
Linked drugAMOXICILLIN
Linked drugAMPICILLIN SODIUM
Linked drugCEFIDEROCOL
Linked drugCEFIDEROCOL SULFATE TOSYLATE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with bacterial disease because it currently carries approved-linked support. Linked drugs include AMOXICILLIN, AMPICILLIN, AZTREONAM, CEFACLOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasebacterial disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
0
Tested Compounds
1
Assay Types
Binding — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine